Hausman G J
Acta Anat (Basel). 1982;112(3):185-96. doi: 10.1159/000145510.
The relationship between mammary gland development and adipocyte formation in rat subcutaneous tissue was studied. Tissue samples from newborn rats and young rats were prepared for histological and histochemical analysis. The development of subcutaneous adipocytes in the young rat is associated temporally and spatially with mammary gland development. The growing mammary gland ducts and the blood vessels and nerves that serve the ducts may physically interact with connective tissue cells, resulting in a population of undifferentiated cells. Adipocytes and a wide variety of cell types may be derived from this pool of undifferentiated cells. Histochemical characteristics of cells of immature ends of mammary gland ducts indicated hypoxic conditions. These conditions may have directed a vascularization process that resulted in network of adipocytes and capillaries around mammary gland ducts. Thus, under normal conditions, adipocyte formation is an integral phase of mammary gland development in the fetal and young rat.
研究了大鼠皮下组织中乳腺发育与脂肪细胞形成之间的关系。制备新生大鼠和幼鼠的组织样本用于组织学和组织化学分析。幼鼠皮下脂肪细胞的发育在时间和空间上与乳腺发育相关。不断生长的乳腺导管以及为导管服务的血管和神经可能与结缔组织细胞发生物理相互作用，从而产生一群未分化细胞。脂肪细胞和多种细胞类型可能来源于这群未分化细胞。乳腺导管未成熟末端细胞的组织化学特征表明存在缺氧状态。这些条件可能引导了一个血管化过程，导致乳腺导管周围形成脂肪细胞和毛细血管网络。因此，在正常情况下，脂肪细胞形成是胎儿和幼鼠乳腺发育的一个组成阶段。
