Poser S, Bauer H J, Poser W
Acta Neurol Scand. 1982 Apr;65(4):347-54. doi: 10.1111/j.1600-0404.1982.tb03091.x.
Clinical data and the prognosis are presented for an epidemiological group of multiple sclerosis (MS) patients. Symptoms and signs of MS, with the exception of optic nerve involvement, were less frequent in the group of 221 patients from the epidemiological area of Southern Lower Saxony than in the hospital series (n = 1837), although the mean duration of the disease was somewhat longer in the epidemiological group. Fifty-two percent of the latter were unrestricted or minimally restricted upon examination compared to 26% of the hospital group. Taking a progression index as a measure for prognosis (disability grade divided by the duration of the disease) 36% of the epidemiological group belonged to a benign category compared to 16% in the hospital group. The progress of these patients was not more than 1 grade of disability within a 5-year-period (progression index 0.2 or less). A malignant course was defined as a progression of at least 7 grades during a 5-year period (progression index 1.4 or more). Ten percent of the hospital series belonged to this category compared to 2% of the epidemiological group. Thus data from a representative group of patients show that the overall prognosis of MS is considerably better than generally suspected.
本文呈现了一组多发性硬化症（MS）患者的临床数据及预后情况。在下萨克森州南部流行病学区域的221例患者中，除视神经受累外，MS的症状和体征出现频率低于医院系列病例（n = 1837），尽管该流行病学组的疾病平均病程略长。经检查，该组中52%的患者无限制或仅有轻微限制，而医院组这一比例为26%。以进展指数作为预后衡量指标（残疾等级除以病程），流行病学组中36%属于良性类别，而医院组为16%。这些患者在5年内残疾进展不超过1级（进展指数为0.2或更低）。恶性病程定义为5年内至少进展7级（进展指数为1.4或更高）。医院系列病例中有10%属于这一类别，而流行病学组为2%。因此，来自一组具有代表性患者的数据表明，MS的总体预后比普遍怀疑的要好得多。
