Raftery E B, Mann S, BalaSubramanian V, Craig M W
Am Heart J. 1982 Aug;104(2 Pt 2):417-20. doi: 10.1016/0002-8703(82)90132-6.
Ambulatory monitoring of intra-arterial blood pressure was used to assess patterns of circadian blood pressure in 12 hypertensive patients who were treated with pindolol in either a once- or twice-daily dosage regimen. Neither once-daily nor twice-daily pindolol had much effect during the latter part of the night and early morning. In the six patients who agreed to further crossover studies, the hypotensive effects of once-daily therapy were not significantly different from those produced by a twice-daily regimen. While confirming the effectiveness of once-daily beta blockade in hypertension, we deduce that failure to affect nighttime blood pressure substantially is a feature independent of the dosage regimen and also, probably, of the individual beta blocker used.
采用动态动脉血压监测评估12例高血压患者的昼夜血压模式，这些患者接受了每日一次或两次剂量方案的吲哚洛尔治疗。无论是每日一次还是每日两次的吲哚洛尔，在夜间后期和清晨期间都没有太大效果。在同意进行进一步交叉研究的6例患者中，每日一次治疗的降压效果与每日两次方案产生的效果没有显著差异。在证实每日一次β受体阻滞剂治疗高血压有效性的同时，我们推断未能显著影响夜间血压是一个独立于剂量方案且可能也独立于所用个体β受体阻滞剂的特征。
