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阿昔洛韦与碘苷治疗溃疡性疱疹性角膜炎的比较。

A comparison of acyclovir and idoxuridine as treatment for ulcerative herpetic keratitis.

作者信息

Coster D J, Wilhelmus K R, Michaud R, Jones B R

出版信息

Br J Ophthalmol. 1980 Oct;64(10):763-5. doi: 10.1136/bjo.64.10.763.

DOI:10.1136/bjo.64.10.763
PMID:7000170
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1043812/
Abstract

Sixty patients were treated with either acyclovir 2% ointment or idoxuridine 1% ointment 5 times a day in a stratified randomised double-blind clinical trial. The 2 antiviral agents were equally effective.

摘要

在一项分层随机双盲临床试验中，60名患者接受了每天5次的2%阿昔洛韦软膏或1%碘苷软膏治疗。这两种抗病毒药物疗效相当。

相似文献

1
A comparison of acyclovir and idoxuridine as treatment for ulcerative herpetic keratitis.阿昔洛韦与碘苷治疗溃疡性疱疹性角膜炎的比较。
Br J Ophthalmol. 1980 Oct;64(10):763-5. doi: 10.1136/bjo.64.10.763.
2
Randomised double-blind trial of acyclovir and idoxuridine in dendritic corneal ulceration.阿昔洛韦与碘苷治疗树枝状角膜溃疡的随机双盲试验。
Br J Ophthalmol. 1980 Oct;64(10):766-9. doi: 10.1136/bjo.64.10.766.
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A randomised double-blind clinical trial of acyclovir (Zovirax) and adenine arabinoside in herpes simplex corneal ulceration.阿昔洛韦（无环鸟苷）与阿糖腺苷治疗单纯疱疹性角膜溃疡的随机双盲临床试验
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4
[Superficial herpes simplex keratitis. Double-blind comparative trial of acyclovir and idoxuridine (author's transl)].[单纯疱疹性浅层角膜炎。阿昔洛韦与碘苷的双盲对比试验（作者译）]
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5
Acyclovir in herpes keratitis.阿昔洛韦用于疱疹性角膜炎。
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6
Acyclovir treatment of experimental herpetic keratitis in the rabbit eye.阿昔洛韦对兔眼实验性单纯疱疹性角膜炎的治疗
Am J Med. 1982 Jul 20;73(1A):109-11. doi: 10.1016/0002-9343(82)90074-2.
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A double-blind, multicenter clinical trial of acyclovir vs idoxuridine for treatment of epithelial herpes simplex keratitis.阿昔洛韦与碘苷治疗上皮性单纯疱疹性角膜炎的双盲、多中心临床试验。
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Herpetic iridocyclitis.疱疹性虹膜睫状体炎
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Acyclovir and idoxiuridine treatment of herpes simplex keratitis--a double blind clinical study.阿昔洛韦和碘苷治疗单纯疱疹性角膜炎——一项双盲临床研究。
Acta Ophthalmol (Copenh). 1982 Oct;60(5):838-44. doi: 10.1111/j.1755-3768.1982.tb06748.x.
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Comparative trial of acyclovir and adenine arabinoside in the treatment of herpes simplex corneal ulcers.阿昔洛韦与阿糖腺苷治疗单纯疱疹性角膜溃疡的对比试验
Br J Ophthalmol. 1981 Sep;65(9):610-3. doi: 10.1136/bjo.65.9.610.

引用本文的文献

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A systematic review and meta-analysis to compare the efficacy of acyclovir 3% ophthalmic ointment to idoxuridine in curing herpetic keratitis by Day 7 of treatment.一项系统评价和荟萃分析，比较阿昔洛韦3%眼膏与碘苷在治疗第7天时治愈疱疹性角膜炎的疗效。
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Cochrane Database Syst Rev. 2015 Jan 9;1(1):CD002898. doi: 10.1002/14651858.CD002898.pub5.
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Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis.单纯疱疹病毒性上皮性角膜炎的抗病毒治疗及其他治疗干预措施。
Cochrane Database Syst Rev. 2010 Dec 8(12):CD002898. doi: 10.1002/14651858.CD002898.pub4.
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Ganciclovir ophthalmic gel, 0.15%: a valuable tool for treating ocular herpes.0.15%更昔洛韦眼用凝胶：治疗眼部疱疹的宝贵工具。
Clin Ophthalmol. 2007 Dec;1(4):441-53.
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Epidemiology and molecular analysis of herpes simplex keratitis requiring primary penetrating keratoplasty.需要初次穿透性角膜移植术的单纯疱疹性角膜炎的流行病学及分子分析
Br J Ophthalmol. 2004 Oct;88(10):1285-8. doi: 10.1136/bjo.2003.040162.
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The treatment of herpes simplex virus epithelial keratitis.单纯疱疹病毒性上皮性角膜炎的治疗
Trans Am Ophthalmol Soc. 2000;98:505-32.
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A randomised double-blind clinical trial of acyclovir (Zovirax) and adenine arabinoside in herpes simplex corneal ulceration.阿昔洛韦（无环鸟苷）与阿糖腺苷治疗单纯疱疹性角膜溃疡的随机双盲临床试验
Br J Ophthalmol. 1982 Jun;66(6):361-3. doi: 10.1136/bjo.66.6.361.
8
A double-controlled evaluation of acyclovir and vidarabine for the treatment of herpes simplex epithelial keratitis.阿昔洛韦与阿糖腺苷治疗单纯疱疹性上皮性角膜炎的双对照评估。
Trans Am Ophthalmol Soc. 1981;79:168-79.
9
Comparative trial of acyclovir and adenine arabinoside in the treatment of herpes simplex corneal ulcers.阿昔洛韦与阿糖腺苷治疗单纯疱疹性角膜溃疡的对比试验
Br J Ophthalmol. 1981 Sep;65(9):610-3. doi: 10.1136/bjo.65.9.610.
10
Acyclovir and trifluorothymidine in herpetic keratitis: a multicentre trial.阿昔洛韦与三氟胸腺嘧啶治疗疱疹性角膜炎：一项多中心试验
Br J Ophthalmol. 1982 Aug;66(8):506-8. doi: 10.1136/bjo.66.8.506.

本文引用的文献

1
Role of debridement in the treatment of herpetic keratitis.清创术在单纯疱疹性角膜炎治疗中的作用。
Trans Ophthalmol Soc U K (1962). 1977 Jul;97(2):314-7.
2
9-(2-hydroxyethoxymethyl) guanine activity against viruses of the herpes group.9-（2-羟乙氧甲基）鸟嘌呤对疱疹病毒组病毒的活性。
Nature. 1978 Apr 13;272(5654):583-5. doi: 10.1038/272583a0.
3
Treatment of amoeboid herpetic ulcers with adenine arabinoside or trifluorothymidine.用阿糖腺苷或三氟胸苷治疗阿米巴样疱疹性溃疡。
Br J Ophthalmol. 1979 Jun;63(6):418-21. doi: 10.1136/bjo.63.6.418.
4
Acycloguanosine: antiviral activity in the rabbit cornea.阿昔洛韦：兔角膜中的抗病毒活性。
Br J Ophthalmol. 1979 Jun;63(6):422-4. doi: 10.1136/bjo.63.6.422.
5
Efficacy of acycloguanosine (Wellcome 248U) against herpes-simplex corneal ulcers.阿昔洛韦（威康248U）治疗单纯疱疹性角膜溃疡的疗效。
Lancet. 1979 Feb 3;1(8110):243-4. doi: 10.1016/s0140-6736(79)90769-4.