Aono T, Aki T, Koike K, Kurachi K
Am J Obstet Gynecol. 1982 Aug 15;143(8):927-32. doi: 10.1016/0002-9378(82)90476-8.
Forty-two primiparous and 54 multiparous women with total yields of milk not exceeding 50 ml for the first 3 postpartum days were treated with 100 mg of oral sulpiride or placebo for 4 days from the third postpartum day. In the primiparous mothers, the mean daily yield of milk in the sulpiride group increased significantly (p less than 0.01) over that in the control group after the fourth postpartum day. Mean (+/- SE) total volumes of milk for the third to fifth postpartum days were 661.5 +/- 64.4 and 441.2 +/- 51.2 ml in the sulpiride and the control groups, respectively. However, in the multiparous mothers, no significant difference between the control and the sulpiride group was noted in total yield of milk, since a good increase in the secretion of milk was obtained without medication in these mothers. Determinations of daily serum levels of prolactin in 20 primiparous women revealed significantly higher concentrations in the sulpiride group. The ratio of primiparous mothers with complete breast-feeding 1 month after delivery was higher in the sulpiride group (55%) than in the control group (30%), whereas there was no difference between the control group and the sulpiride group of multiparous women. These data indicate that poor initiation of puerperal lactation in primiparous mothers can be effectively treated with oral sulpiride.
42名初产妇和54名经产妇，产后头3天的总产奶量不超过50毫升，从产后第3天起，用100毫克口服舒必利或安慰剂治疗4天。在初产妇中，舒必利组产后第4天之后的日均产奶量比对照组显著增加（p小于0.01）。舒必利组和对照组产后第3至5天的平均（±标准误）总产奶量分别为661.5±64.4毫升和441.2±51.2毫升。然而，在经产妇中，舒必利组和对照组的总产奶量没有显著差异，因为这些经产妇在未用药的情况下产奶量也有良好增加。对20名初产妇每日血清催乳素水平的测定显示，舒必利组的浓度显著更高。舒必利组产后1个月完全母乳喂养的初产妇比例（55%）高于对照组（30%），而经产妇的对照组和舒必利组之间没有差异。这些数据表明，初产妇产后泌乳启动不佳可用口服舒必利有效治疗。
