Polatti F
Clin Exp Obstet Gynecol. 1982;9(3):144-7.
The effect of oral administration of sulpiride isomers on PRL secretion and breast engorgement was studied in 60 multiparous nursing mothers, according to a double blind schedule: 45 women were orally given 50 mg sulpiride (L, D, L-D form) twice daily during the first 5 days of puerperium, 15 were given a placebo in the same way. Basal, the 3rd and 5th day serum PRL levels were determined and every day milk secretion was evaluated. On milk samples obtained on the 5th day, sulpiride concentration was measured. 40 women with insufficient lactation and 20 with total lack of milk, 25-40 days after delivery, were treated in the same way, in double blind. Milk secretion was evaluated at the beginning and at the 5th, 10th and 15th day. The mean total milk yield (+/- S.D.) during the first 5 postpartum days in sulpiride groups were significantly greater than that in the control group. Plasma PRL levels resulted significantly higher in sulpiride treated groups than in placebo group. All women with insufficient or absent milk secretion could avoid supplemental bottle-feeding after 10 days of treatment.
按照双盲方案，对60名经产妇哺乳期母亲研究了口服舒必利异构体对催乳素分泌和乳房充盈的影响：45名妇女在产褥期的头5天每天口服两次50毫克舒必利（L，D，L-D形式），15名以同样方式给予安慰剂。测定基础、第3天和第5天的血清催乳素水平，并每天评估乳汁分泌情况。在第5天采集的乳汁样本上测量舒必利浓度。对40名产后25 - 40天泌乳不足和20名完全无乳汁分泌的妇女，同样采用双盲法进行治疗。在开始时以及第5、10和15天评估乳汁分泌情况。舒必利组产后头5天的平均总产奶量（±标准差）显著高于对照组。舒必利治疗组的血浆催乳素水平显著高于安慰剂组。所有泌乳不足或无乳汁分泌的妇女在治疗10天后都可避免补充奶瓶喂养。
