Aono T, Shioji T, Aki T, Hirota K, Nomura A, Kurachi K
J Clin Endocrinol Metab. 1979 Mar;48(3):478-82. doi: 10.1210/jcem-48-3-478.
The effect of oral administration of sulpiride on PRL secretion and initiation of puerperal lactation was studied in 130 randomly selected primiparous nursing mothers. Sixty-six women were given 50 mg sulpiride orally twice a day during the first 7 days of the puerperium (sulpiride group). Sixty-four women were given a placebo in the same way (control group). The mean (+/-SE) total milk yield during the first 5 postpartum days in the sulpiride group (1211.7 +/- 65.0 ml) was significantly greater than that in the control group (916.0 +/- 66.0 ml). Every other day determinations of serum PRL levels revealed significantly higher concentrations in the sulpiride group than in the control group. A single oral dose of 50 mg sulpiride raised serum PRL levels for 12 h, with a peak level at 2 h after dosing in 7 women on the second postpartum day. These data suggest that sulpiride given orally promotes the initiation of lactation in puerperal women by stimulating PRL secretion.
在130名随机选择的初产哺乳母亲中，研究了口服舒必利对催乳素（PRL）分泌及产后泌乳启动的影响。66名妇女在产褥期的前7天每天口服两次50毫克舒必利（舒必利组）。64名妇女以同样方式服用安慰剂（对照组）。舒必利组产后第1至5天的平均（±标准误）总产奶量（1211.7±65.0毫升）显著高于对照组（916.0±66.0毫升）。每隔一天测定血清PRL水平显示，舒必利组的浓度显著高于对照组。产后第2天，7名妇女单次口服50毫克舒必利使血清PRL水平升高12小时，给药后2小时达到峰值。这些数据表明，口服舒必利通过刺激PRL分泌促进产褥期妇女泌乳的启动。
