Lane R S, Emmons R W, Devlin V, Dondero D V, Nelson B C
Am J Trop Med Hyg. 1982 Jul;31(4):837-43. doi: 10.4269/ajtmh.1982.31.837.
A virus very similar or identical to Colorado tick fever (CTF) virus was recovered from the blood clot of one of 104 black-tailed jack rabbits (Lepus californicus) examined during a survey for various zoonotic agents in mammals and ticks from the University of California, Hopland Field Station, Mendocino County, California, 1974--79. This is the first reported isolation of a CTF-like virus from L. californicus, and only the second time such a virus has been found in northwestern California. Mendocino County is located far outside the known distributional ranges of the most common mammalian hosts of CTF virus and of Dermacentor andersoni, the only proven tick vector for man. The viral isolate is very similar to a CTF-like virus previously recovered from the blood and spleen of a western gray squirrel (Sciurus griseus) from San Luis Obispo County, an area also outside of the previously-known CTF area. Virus was not isolated from 14 additional species of mammals (354 specimens) or from eight species of ticks (4,487 individuals), but CTF-neutralizing antibodies were detected in 28 of 771 (3.6%) sera from seven of 15 mammalian species including significant titers (greater than or equal to 1:8) in two species and one subspecies not previously reported as natural hosts, i.e., brush mouse (Peromyscus boylii), pinyon mouse (P. truei), and Columbian black-tailed deer (Odocoileus hemionus columbianus). CTF indirect immunofluorescent antibodies also were detected in 26 of 129 (20.2%) sera belonging to four of five mammalian species tested. Neutralizing antibodies were found in sera of deer from other localities in Mendocino County, from a deer mouse from Napa County, and from a brush rabbit from Monterey County as well. These findings suggest that a virus identical or similar to CTF virus is widespread in northwestern-westcentral California, and that surveillance for human cases of CTF or a similar disease should be extended to cover this region.
1974年至1979年期间，在加利福尼亚大学霍普兰德野外站对加利福尼亚州门多西诺县的哺乳动物和蜱虫进行的各种人畜共患病原体调查中，从104只黑尾长耳大野兔（Lepus californicus）中的一只的血凝块中分离出一种与科罗拉多蜱传热（CTF）病毒非常相似或相同的病毒。这是首次报道从加利福尼亚长耳大野兔中分离出CTF样病毒，也是第二次在加利福尼亚州西北部发现这种病毒。门多西诺县位于CTF病毒最常见的哺乳动物宿主以及唯一经证实的人类蜱虫传播媒介安德逊革蜱（Dermacentor andersoni）已知分布范围之外。该病毒分离株与先前从圣路易斯奥比斯波县的一只西部灰松鼠（Sciurus griseus）的血液和脾脏中分离出的一种CTF样病毒非常相似，该地区也在先前已知的CTF区域之外。在另外14种哺乳动物（354个样本）或8种蜱虫（4487只个体）中未分离到病毒，但在15种哺乳动物中的7种的771份血清中有28份（3.6%）检测到CTF中和抗体，其中包括两种之前未被报道为天然宿主的物种和一个亚种中出现了显著滴度（大于或等于1:8），即灌丛鼠（Peromyscus boylii）、食松子鼠（P. truei）和哥伦比亚黑尾鹿（Odocoileus hemionus columbianus）。在测试的5种哺乳动物中的4种的129份血清中有26份（20.2%）也检测到了CTF间接免疫荧光抗体。在门多西诺县其他地区的鹿血清、纳帕县的一只鹿鼠血清以及蒙特雷县的一只灌丛兔血清中也发现了中和抗体。这些发现表明，一种与CTF病毒相同或相似的病毒在加利福尼亚州西北部至中西部广泛存在，并且对CTF或类似疾病的人类病例监测应扩大到该地区。
