Lehman R H, Cox J D, Belson T P, Yale R S, Byhardt R W, Toohill R J, Malin T C
Am J Otolaryngol. 1982 May-Jun;3(3):174-81. doi: 10.1016/s0196-0709(82)80051-3.
Recurrence patterns were examined by stage of disease and treatment modality in 139 patients with 141 squamous cell carcinomas of the floor of the mouth and oral tongue, reflecting an 11-year experience at two hospitals. Treatment categories included surgery, irradiation, and combined treatment. Patients who were without evidence of disease at two years, or at the time of death, were considered cured. Cures were achieved in 87 per cent of patients with Stage I disease, 83 per cent with Stage II, 40 per cent with Stage III, and 34 per cent with Stage IV. Similar results were achieved by irradiation alone and by surgery alone in controlling early lesions. Combined treatment offered the best chance of cure for patients with advanced disease. Failure was most often associated with persistence at the primary site. No patient with advanced disease was salvaged after local treatment failure. One of 51 patients who received prophylactic treatment of the neck in the absence of clinical evidence of metastases had a regional treatment failure, while seven of 26 such patients who did not receive prophylactic treatment developed regional metastases. The ten-year adjusted survival rate, as calculated by the actuarial method, was 53 +/- 4.7 per cent. Forty-two multiple primary lesions were found in the 139 patients.
对139例患有141例口底和舌鳞状细胞癌的患者，根据疾病分期和治疗方式检查复发模式，这反映了两家医院11年的经验。治疗类别包括手术、放疗和联合治疗。在两年时或死亡时无疾病证据的患者被视为治愈。I期疾病患者的治愈率为87%，II期为83%，III期为40%，IV期为34%。单独放疗和单独手术在控制早期病变方面取得了相似的结果。联合治疗为晚期疾病患者提供了最佳的治愈机会。失败最常与原发部位的持续存在有关。局部治疗失败后，没有晚期疾病患者得到挽救。51例在无临床转移证据时接受颈部预防性治疗的患者中有1例出现区域治疗失败，而26例未接受预防性治疗的此类患者中有7例发生区域转移。采用精算方法计算的十年调整生存率为53±4.7%。在139例患者中发现了42例多原发性病变。
