Mathur P P, Chattopadhyay S
Andrologia. 1982 Mar-Apr;14(2):171-6. doi: 10.1111/j.1439-0272.1982.tb03120.x.
Flutamide, an antiandrogen, increases the levels of plasma luteinizing hormone (LH), stimulates steroidogenesis in the testis and antagonizes the biological expression of androgen on target organs. flutamide was administered to rats to study intracellular mechanism in the testis where steroidogenesis was stimulated in the presence of an antiandrogen. The weights of ventral prostate and seminal vesicles showed antiandrogenic effects of flutamide. However, the availability of testosterone was reflected by the increased activity of kidney beta glucuronidase. The weight of testis and the incorporation of 32P in its nucleic acid fraction at 45 minutes were increased. The concentrations of testicular DNA and ascorbic acid were decreased. Activity of the lysosomal enzymes, acid phosphatase and beta glucuronidase, increased in the free state. Thus flutamide provided a condition where changes in the lysosomal stability in association with the alteration of testicular function was demonstrated.
氟他胺是一种抗雄激素药物，可提高血浆黄体生成素（LH）水平，刺激睾丸中的类固醇生成，并拮抗雄激素在靶器官上的生物学表达。给大鼠施用氟他胺以研究睾丸中的细胞内机制，在该机制中，在存在抗雄激素的情况下类固醇生成受到刺激。腹侧前列腺和精囊的重量显示出氟他胺的抗雄激素作用。然而，肾脏β-葡萄糖醛酸酶活性的增加反映了睾酮的可用性。睾丸重量以及45分钟时其核酸部分中32P的掺入量增加。睾丸DNA和抗坏血酸的浓度降低。溶酶体酶、酸性磷酸酶和β-葡萄糖醛酸酶的活性在游离状态下增加。因此，氟他胺提供了一种条件，证明了溶酶体稳定性的变化与睾丸功能的改变有关。
