Creasey W A, Thrall D E
Am J Vet Res. 1982 Jun;43(6):1015-8.
Nine dogs with spontaneous oral fibrosarcomas were given the radiosensitizer misonidazole (Ro-07-0582) In combination with orthovoltage radiotherapy. Although there appeared to be a trend toward greater disease-free survival of these animals as compared with a group of 13 dogs with similar tumors treated by orthovoltage x-rays alone, on analysis there was no significant difference. The plasma half-life and the volume of distribution of misonidazole were determined as 4.95 hours and 15.1 L/m2, respectively. In 3 dogs with evidence of misonidazole toxicosis, plasma concentrations at 4 hours after the dose exceeded 85 microgram/ml, and the areas under the concentration vs time curve for this first 10 hours were greater than 850 microgram.hr/ml.
9只患有自发性口腔纤维肉瘤的犬接受了放射增敏剂米索硝唑（Ro-07-0582）与常压放疗联合治疗。尽管与另一组仅接受常压X线治疗的13只患有相似肿瘤的犬相比，这些动物似乎有更长无病生存期的趋势，但经分析无显著差异。米索硝唑的血浆半衰期和分布容积分别测定为4.95小时和15.1 L/m²。在3只出现米索硝唑中毒迹象的犬中，给药后4小时的血浆浓度超过85微克/毫升，且前10小时浓度-时间曲线下面积大于850微克·小时/毫升。
