Brewer W G, Turrel J M
J Am Vet Med Assoc. 1982 Jul 15;181(2):146-50.
Ten dogs with oral or external nasal fibrosarcoma were treated sequentially with orthovoltage radiation and radiofrequency (RF)-induced hyperthermia. Total radiation doses ranged from 3,200 to 4,800 rad given in 8 to 12 fractions of 400 rad. Immediately after 2 to 4 radiation treatments, hyperthermia was given. Six oral fibrosarcomas were heated to 50 C for 30 sec, using a hand-held RF generator. Four nasomaxillary fibrosarcomas were heated to 43 C for 30 minutes, using a 500-kHz RF generator. Hyperthermia of 50 C resulted in tumor necrosis and infection in 3 dogs and fatal septicemia in 1 dog. Nine of 10 tumors responded to therapy. One year after therapy, 5 dogs were free of disease. Tumor regrowth occurred in 5 dogs. Mean time to tumor regrowth and mean survival time of all dogs were 343 and 398 days, respectively. The results suggested that sequential radiation-hyperthermia is an effective therapeutic regimen for canine fibrosarcoma. It was concluded that this modality not only may be beneficial in the treatment of canine tumors but may be useful for designing new therapeutic approaches to similar tumors in man.
十只患有口腔或外鼻纤维肉瘤的犬依次接受了深部X线放疗和射频（RF）诱导的热疗。总辐射剂量为3200至4800拉德，分8至12次给予，每次400拉德。在进行2至4次放射治疗后，立即进行热疗。六只口腔纤维肉瘤犬使用手持式射频发生器加热至50℃，持续30秒。四只鼻上颌纤维肉瘤犬使用500千赫的射频发生器加热至43℃，持续30分钟。50℃的热疗导致3只犬出现肿瘤坏死和感染，1只犬出现致命性败血症。10只肿瘤中有9只对治疗有反应。治疗后一年，5只犬无疾病。5只犬出现肿瘤复发。所有犬的肿瘤复发平均时间和平均生存时间分别为343天和398天。结果表明，序贯放疗-热疗是犬纤维肉瘤的一种有效治疗方案。得出的结论是，这种治疗方式不仅可能对犬类肿瘤的治疗有益，而且可能有助于设计针对人类类似肿瘤的新治疗方法。
