Thrall D E
J Am Vet Med Assoc. 1981 Jul 15;179(2):159-62.
Seventeen dogs with oral fibrosarcomas were referred for radiotherapy. All dogs were treated with orthovoltage x-rays at doses that approached the tolerance level of normal tissue. Acceptable normal tissue complications (epilation, mucositis, and moist desquamation) developed in all dogs surviving radiotherapy. Osteonecrosis, an unacceptable complication of radiotherapy, developed in 2 dogs. Of the 17 treated dogs, 2 died before radiotherapy was completed and 2 lived less than 1 month after treatment. One of the 17 was alive, with osteonecrosis, 27 months after radiotherapy and was free of tumor. The mean time to tumor regrowth and mean survival time in the other 12 dogs were 3.9 and 6.8 months, respectively. The results indicated a poor response of oral fibrosarcomas to treatment with orthovoltage x-rays. It was concluded that treatment of oral fibrosarcomas with other modalities, eg, 60Co gamma rays, may lead to improved results.
17只患有口腔纤维肉瘤的犬被转诊接受放射治疗。所有犬均接受了接近正常组织耐受水平剂量的常压X线治疗。所有放疗后存活的犬均出现了可接受的正常组织并发症（脱毛、黏膜炎和湿性脱皮）。2只犬出现了放疗不可接受的并发症——骨坏死。17只接受治疗的犬中，2只在放疗完成前死亡，2只在治疗后存活时间不到1个月。17只中有1只在放疗后27个月时存活，患有骨坏死，但无肿瘤。其他12只犬肿瘤复发的平均时间和平均生存时间分别为3.9个月和6.8个月。结果表明口腔纤维肉瘤对常压X线治疗反应不佳。得出的结论是，用其他方式（如60Coγ射线）治疗口腔纤维肉瘤可能会取得更好的效果。
