Manthei U, Taussig L M, Beckerman R C, Strunk R C
Am Rev Respir Dis. 1982 Aug;126(2):253-7. doi: 10.1164/arrd.1982.126.2.253.
The presence or absence of circulating immune complexes (CIC) was studied longitudinally over a period of 15 months in 17 patients with cystic fibrosis. (CF). Using the Raji cell assay, CIC were found in 47% of patients. Presence of immune complexes did not correlate with age at midpoint of the study severity of disease, acute pulmonary exacerbations, progression of lung disease, or nonspecific, humoral and cellular immune functions. In addition, the presence of CIC did not correlate with colonization with Pseudomonas aeruginosa, Staphylococcus aureus, Hemophilus influenzae, or streptococcus species (viridans or pneumoniae). Because CIC were present in patients without concurrent sputum colonization with Pseudomonas aeruginosa, antigens other than components of this organism may be capable of forming CIC in CF. The clinical and pathologic significant of CIC in CF remains to be determined.
在15个月的时间里，对17例囊性纤维化（CF）患者的循环免疫复合物（CIC）的存在与否进行了纵向研究。使用Raji细胞检测法，发现47%的患者存在CIC。免疫复合物的存在与研究中期的年龄、疾病严重程度、急性肺部加重、肺部疾病进展或非特异性、体液和细胞免疫功能均无相关性。此外，CIC的存在与铜绿假单胞菌、金黄色葡萄球菌、流感嗜血杆菌或链球菌属（草绿色链球菌或肺炎链球菌）的定植也无相关性。由于在没有同时伴有铜绿假单胞菌痰定植的患者中也存在CIC，因此除该生物体成分之外的其他抗原可能也能够在CF中形成CIC。CF中CIC的临床和病理意义仍有待确定。
