Bevan R D, Tsuru H
Circ Res. 1981 Aug;49(2):478-85. doi: 10.1161/01.res.49.2.478.
We studied the tissue weight, dimensions, contractility, elasticity, and sensitivity to exogenous norepinephrine (NE) of denervated and innervated segments of the central ear arteries of white New Zealand rabbits. Three different age groups received unilateral superior cervical ganglionectomies, "growing" at 3-4 weeks, "young adult" at 9-11 weeks, and "mature" at 16-20 weeks. In the growing group, 8 weeks after ganglionectomy, the denervated arteries showed mean decreases in tissue weight (11%), total wall thickness (12+), cross-sectional area of media (17%), contractility (16%), and increases in the tangential modulus of elasticity and sensitivity to NE (2.3-fold) compared to the contralateral control vessels. The change in medial cross-sectional area was significant in the growing and young adult but not the mature animals. The other changes, however, although consistently seen, differed quantitatively among the groups. These results indicate that an intact innervation is necessary for normal development and maintenance of the artery wall. However, the precise consequences of this influence vary at different ages. Whether this influence involves a special trophic factor is not known.
我们研究了新西兰白兔中耳中央动脉去神经支配和有神经支配节段的组织重量、尺寸、收缩性、弹性以及对外源性去甲肾上腺素（NE）的敏感性。三个不同年龄组接受了单侧颈上神经节切除术，“生长组”为3 - 4周龄，“青年成年组”为9 - 11周龄，“成熟组”为16 - 20周龄。在生长组中，神经节切除术后8周，与对侧对照血管相比，去神经支配的动脉组织重量平均下降（11%），总壁厚下降（12%），中膜横截面积下降（17%），收缩性下降（16%），而弹性切变模量和对NE的敏感性增加（2.3倍）。中膜横截面积的变化在生长组和青年成年组中显著，但在成熟动物中不显著。然而，其他变化虽然一直可见，但在各组之间存在数量差异。这些结果表明，完整的神经支配对于动脉壁的正常发育和维持是必要的。然而，这种影响的确切后果在不同年龄有所不同。这种影响是否涉及一种特殊的营养因子尚不清楚。
