Constable I, Mohamed S, Tan P L
Aust J Ophthalmol. 1982 Feb;10(1):5-11.
Very high viscosity (12500 centistokes) liquid silicone was injected into the vitreous of 47 eyes of 46 patients with complicated retinal detachment over a two year period. Only eyes judged inoperable by scleral buckling and/or vitrectomy techniques were considered. Complete anatomical reattachment was achieved in 34 cases (72%) while partial reattachment was achieved in a further six cases (13%). All eyes in which complete or partial retinal reattachment was achieved showed improvement in vision but this was usually restricted to count fingers or 6/60 at 3 months to 2 years follow-up. Mounting evidence now suggests that previous clinical opinions claiming an unacceptable toxicity rate with liquid silicone may be misleading.
在两年时间里,将极高粘度(12500厘沲)的液态硅胶注入46例复杂性视网膜脱离患者的47只眼中。仅考虑那些通过巩膜扣带术和/或玻璃体切除术技术判断为无法手术的眼睛。34例(72%)实现了完全解剖复位,另有6例(13%)实现了部分复位。所有实现完全或部分视网膜复位的眼睛视力均有改善,但在3个月至2年的随访中,视力通常仅恢复到能数手指或6/60。越来越多的证据表明,以往声称液态硅胶毒性率不可接受的临床观点可能具有误导性。