Caulet T, Patey M, Pluot M, Roth A, Dousset H
Ann Pathol. 1982;2(2):133-40.
The case of a 36 year old man who presented prominent bilateral cervical lymphadenopathies is reported. The diagnosis of sinus histiocytosis with massive lymphadenopathy (Rosai and Dorfman, 1969) was retained on account of a massive hyperplasia of foamy histiocytes with PAS + inclusions, lipidic storage and hemocytophagy in the sinuses and cords of the lymph nodes. The patient died after 34 months evolution. At the autopsy an important proliferation by large atypical sometimes multinucleated cells in the lymph nodes, liver, bone and spleen was found, as observed in malignant histiocytosis. The ultrastructural study confirmed the histiocytic nature of the cells. The interest of immunohistochemical studies on paraffin embedded material with characterization of tumor histiocytes with lysozyme and alpha 1 antichymotrypsin is discussed. This report described an unusual form of malignant histiocytosis simulating on his early phase sinus histiocytosis with massive lymphadenopathy.
报告了一例36岁男性患者，其双侧颈部淋巴结肿大明显。鉴于淋巴结窦和索条中泡沫状组织细胞大量增生，伴有PAS阳性包涵体、脂质储存和血细胞吞噬现象，最终确诊为伴有巨大淋巴结病的窦性组织细胞增生症（罗萨伊和多夫曼，1969年）。患者在病程34个月后死亡。尸检发现，在淋巴结、肝脏、骨骼和脾脏中存在大量由大型非典型细胞（有时为多核细胞）构成的增殖，这与恶性组织细胞增生症所见相同。超微结构研究证实了这些细胞的组织细胞性质。讨论了对石蜡包埋材料进行免疫组织化学研究的意义，该研究通过溶菌酶和α1抗胰凝乳蛋白酶对肿瘤组织细胞进行了表征。本报告描述了一种不寻常形式的恶性组织细胞增生症，其早期阶段类似伴有巨大淋巴结病的窦性组织细胞增生症。
