甲状腺功能减退症患者的左心室功能。对运动和β肾上腺素能受体阻滞剂的反应。
Left ventricular function in hypothyroidism. Responses to exercise and beta adrenoceptor blockade.
作者信息
Forfar J C, Muir A L, Toft A D
出版信息
Br Heart J. 1982 Sep;48(3):278-84. doi: 10.1136/hrt.48.3.278.
The effects of exercise and beta adrenoceptor blockade on left ventricular function were assessed in eight patients with hypothyroidism before and during thyroxine replacement treatment. Left ventricular ejection fraction, measured by radionuclide ventriculography, was reduced in hypothyroid patients at rest and on exercise. The rise in ejection fraction with exercise was, however, similar in both groups. Pretreatment with intravenous propranolol reduced the ejection fraction at rest 9% in both hypothyroid and euthyroid patients and reduced the rise on exercise. Directional changes in a second index of myocardial contractility based on the shape of the ventricular volume curve paralleled the changes in the ejection fraction. Left ventricular function is therefore reversibly depressed by thyroid hormone deficiency but responses to exercise and beta adrenoceptor blockade are normal. There is no evidence of altered adrenergic sensitivity in the control of myocardial contractility in hypothyroidism.
在八名甲状腺功能减退患者中，于甲状腺素替代治疗前及治疗期间，评估了运动和β肾上腺素能受体阻滞剂对左心室功能的影响。通过放射性核素心室造影测量，甲状腺功能减退患者静息及运动时的左心室射血分数均降低。然而，两组患者运动时射血分数的升高情况相似。静脉注射普萘洛尔进行预处理，使甲状腺功能减退和甲状腺功能正常的患者静息时射血分数均降低9%，并减少了运动时射血分数的升高。基于心室容积曲线形状的心肌收缩力第二个指标的方向性变化与射血分数的变化平行。因此，甲状腺激素缺乏会使左心室功能可逆性降低，但对运动和β肾上腺素能受体阻滞剂的反应正常。没有证据表明甲状腺功能减退时在心肌收缩力控制方面肾上腺素能敏感性发生改变。
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