Fessas P, Loukopoulos D, Loutradi-Anagnostou A, Komis G
Br J Haematol. 1982 Aug;51(4):577-83. doi: 10.1111/j.1365-2141.1982.tb02821.x.
In a Greek family three cases of beta-thalassaemia intermedia were diagnosed as resulting from the interaction of a typical high HbA2-beta-thalassaemia with an atypical (silent) beta-thalassaemia gene. Following electrophoresis of globins on an acid-urea-Triton-acrylamide system, an otherwise silent beta-like variant was revealed in the carriers of the atypical thalassaemia gene and in the intermediates; it amounted to 33% of the non-alpha chains in the former and to c. 75% in the latter. The provisional name Hb Knossos is suggested for this abnormality.
在一个希腊家庭中，3例中间型β地中海贫血被诊断为由典型的高HbA2-β地中海贫血与非典型（沉默型）β地中海贫血基因相互作用所致。在酸性尿素- Triton -丙烯酰胺系统上对珠蛋白进行电泳后，在非典型地中海贫血基因携带者和中间型患者中发现了一种原本沉默的β样变体；在前者中，它占非α链的33%，在后者中约占75%。建议将这种异常命名为Hb Knossos。
