Paterson M E, Allen J, Jordan J A
Br J Obstet Gynaecol. 1982 Aug;89(8):657-64. doi: 10.1111/j.1471-0528.1982.tb04722.x.
The effects of the climacteric and sequential mestranol and norethisterone on the epithelium of the cervix and genital tract were determined in 12 postmenopausal women. Before treatment the squamocolumnar junction was visible in only six of the 12 women, but after treatment with sequential mestranol and norethisterone the squamocolumnar junction became visible due to a minor degree of eversion. Mucus, which was always absent before therapy, was always seen afterwards and any atrophic effects were reversed by therapy within 3 months. The effects of oestrogen and progestogen deficiency were more easily seen by scanning electron microscopy (SEM) than with conventional histology. Before treatment six of the nine women studied by SEM had a cervix covered by mature squamous epithelium, but after therapy all the women had mature squamous epithelium. The pretreatment lateral vaginal wall and urinary sediment smears showed mainly immature squamous cells; this correlated poorly with the histology and SEM of the cervix. There was a good correlation between urinary sediment and lateral vaginal wall smears both before and after treatment.
对12名绝经后女性测定了更年期以及炔雌醇甲醚和炔诺酮序贯用药对宫颈及生殖道上皮的影响。治疗前，12名女性中只有6名可见鳞柱交界，但在接受炔雌醇甲醚和炔诺酮序贯治疗后，由于轻度外翻，鳞柱交界变得可见。治疗前一直不存在的黏液，治疗后总是可见，且任何萎缩性影响在3个月内通过治疗得以逆转。通过扫描电子显微镜（SEM）比传统组织学更容易观察到雌激素和孕激素缺乏的影响。在接受SEM检查的9名女性中，治疗前有6名宫颈被成熟鳞状上皮覆盖，但治疗后所有女性均有成熟鳞状上皮。治疗前阴道侧壁和尿沉渣涂片主要显示未成熟鳞状细胞；这与宫颈的组织学和SEM结果相关性较差。治疗前后尿沉渣和阴道侧壁涂片之间均具有良好的相关性。
