Paterson M E
Maturitas. 1982 Aug;4(2):83-94. doi: 10.1016/0378-5122(82)90034-2.
A randomised, double-blind, cross-over study into the effect of graded sequential mestranol and norethisterone on climacteric symptoms was performed. The study group consisted of 23 post-menopausal women who had previously undergone hysterectomy. Active therapy resulted in a significant reduction in hot flushes and night sweats. There was a slight improvement in insomnia, lack of energy and confidence but the other symptoms were not significantly altered. A small placebo effect was noted but this was only significant 1 mth after active treatment had been discontinued in the group of women receiving placebo second. Active treatment also resulted in a significant reduction in serum sodium, calcium, albumin, alkaline phosphatase and cholesterol, and increase in serum triglycerides, but no alteration in the other biochemical parameters, weight or blood pressure.
进行了一项关于分级序贯炔雌醇甲醚和炔诺酮对更年期症状影响的随机、双盲、交叉研究。研究组由23名先前已接受子宫切除术的绝经后妇女组成。积极治疗使潮热和盗汗显著减少。失眠、精力不足和信心方面略有改善，但其他症状无显著变化。观察到有轻微的安慰剂效应，但仅在接受第二阶段安慰剂治疗的女性组中停止积极治疗1个月后才显著。积极治疗还导致血清钠、钙、白蛋白、碱性磷酸酶和胆固醇显著降低，血清甘油三酯升高，但其他生化参数、体重或血压无变化。
