Mattsson L A, Cullberg G, Samsioe G
Maturitas. 1982 Aug;4(2):95-102. doi: 10.1016/0378-5122(82)90035-4.
Subjective complaints, endometrial histopathology, vaginal cytology and bleeding patterns were recorded in 26 patients treated with a continuous oestrogen-progestogen regimen for 12 mth. A marked reduction of hot flushes and sweats were noted and the evaluation of endometrial specimens revealed that the mucosae were mostly inactive-atrophic. The karyopyknotic index proved to be a poor indicator of oestrogenic activity. The number of recorded bleedings in the peri-menopausal women differed markedly from the post-menopausal women during treatment; they were very slight in the latter group. Even in those cases where bleeding occurred, the endometrial samples were found to be atrophic. Vaginal bleeding seemed to be an unreliable indicator of endometrial histopathology. The present combination of hormones used in a continuous regimen is a good alternative for post-menopausal women in need of hormonal therapy.
记录了26例接受连续12个月雌激素 - 孕激素治疗方案患者的主观症状、子宫内膜组织病理学、阴道细胞学及出血模式。潮热和盗汗明显减少，对子宫内膜标本的评估显示，黏膜大多呈无活性萎缩状态。核固缩指数被证明是雌激素活性的一个不良指标。围绝经期妇女在治疗期间记录的出血次数与绝经后妇女有显著差异；后者组的出血非常轻微。即使在出现出血的病例中，子宫内膜样本也被发现是萎缩性的。阴道出血似乎是子宫内膜组织病理学的一个不可靠指标。目前连续方案中使用的激素组合对于需要激素治疗的绝经后妇女是一个很好的选择。
