Adler L E, Pachtman E, Franks R D, Pecevich M, Waldo M C, Freedman R
Biol Psychiatry. 1982 Jun;17(6):639-54.
The action of CNS inhibitory neuronal mechanisms was tested in acutely psychotic unmedicated schizophrenic patients and in normal controls. An early positive component of the auditory average evoked response recorded at the vertex 50 msec after a click stimulus was studied. Stimuli were delivered at 10-sec intervals to establish a base-line response. Inhibitory mechanisms were then tested using a conditioning-testing paradigm by assessing the change in response to a second stimulus following the first at either 0.5, 1.0, or 2.0-sec intervals. At the 0.5-sec interval, normal controls had over a 90% mean decrement in response, whereas schizophrenics showed less than a 15% mean decrement. At 2-sec intervals, responses from normals were still 30 to 50% diminished, but those from schizophrenics showed an increased response to the stimulus compared to base line. The data suggest that normally present inhibitory mechanisms are markedly reduced in schizophrenics. Failure of these inhibitory mechanisms may be responsible for the defects in sensory gating which are thought to be an important part of the pathophysiology of schizophrenia.
在未经药物治疗的急性精神病性精神分裂症患者和正常对照中测试了中枢神经系统抑制性神经元机制的作用。研究了在点击刺激后50毫秒在头顶记录的听觉平均诱发电位的早期正向成分。以10秒的间隔给予刺激以建立基线反应。然后使用条件测试范式通过评估在0.5、1.0或2.0秒间隔的第一个刺激之后对第二个刺激的反应变化来测试抑制机制。在0.5秒的间隔时，正常对照的反应平均下降超过90%，而精神分裂症患者的平均下降不到15%。在2秒的间隔时，正常对照的反应仍减少30%至50%，但与基线相比，精神分裂症患者对刺激的反应增加。数据表明，精神分裂症患者中通常存在的抑制机制明显减少。这些抑制机制的失效可能是感觉门控缺陷的原因，而感觉门控缺陷被认为是精神分裂症病理生理学的重要组成部分。
