三磷酸核苷酸诱导大鼠中性粒细胞聚集
Aggregation of rat neutrophils by nucleotide triphosphates.
作者信息
Ford-Hutchinson A W
出版信息
Br J Pharmacol. 1982 Jul;76(3):367-71. doi: 10.1111/j.1476-5381.1982.tb09229.x.
Abstract
1 Adenosine 5'-triphosphate (ATP) and uridine 5'-triphosphate (UTP) at concentrations of 3 x 10(-7)M and greater cause a rapid partially reversible aggregation of rat polymorphonuclear leucocytes. 2 Other nucleotide phosphates are much less active at producing aggregation responses; the agonist potencies being UTP greater than ATP greater than guanosine 5'-triphosphate, cytidine 5'-triphosphate, thymidine 5'-triphosphate; ATP greater than adenosine 5'-diphosphate (ADP) greater than adenosine 5'-monophosphate (AMP); and ADP greater than uridine 5'-diphosphate, thymidine 5'-diphosphate, guanosine 5'-diphosphate, cytidine 5'-diphosphate. Adenosine is inactive. 3 The hydrolysis resistant analogues of ATP, alpha-beta-methylene ATP and beta-gamma-methylene ATP, do not cause neutrophil aggregation suggesting that hydrolysis of ATP and UTP may be required to initiate the aggregation response. 4 It is postulated that ATP and UTP may be important stimulants of neutrophil function and may be involved in the adherence of these cells to the vascular endothelium.
摘要
- 浓度为3×10⁻⁷M及以上的5'-三磷酸腺苷（ATP）和5'-三磷酸尿苷（UTP）可导致大鼠多形核白细胞迅速发生部分可逆性聚集。2. 其他核苷酸磷酸在产生聚集反应方面活性要低得多；激动剂效力顺序为UTP大于ATP大于5'-三磷酸鸟苷、5'-三磷酸胞苷、5'-三磷酸胸苷；ATP大于5'-二磷酸腺苷（ADP）大于5'-单磷酸腺苷（AMP）；以及ADP大于5'-二磷酸尿苷、5'-二磷酸胸苷、5'-二磷酸鸟苷、5'-二磷酸胞苷。腺苷无活性。3. ATP的抗水解类似物α-β-亚甲基ATP和β-γ-亚甲基ATP不会引起中性粒细胞聚集，这表明可能需要ATP和UTP水解才能引发聚集反应。4. 据推测，ATP和UTP可能是中性粒细胞功能的重要刺激物，可能参与这些细胞与血管内皮的黏附。
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