达米尼硬蜱唾液的抗止血、抗炎和免疫抑制特性。
Antihemostatic, antiinflammatory, and immunosuppressive properties of the saliva of a tick, Ixodes dammini.
作者信息
Ribeiro J M, Makoul G T, Levine J, Robinson D R, Spielman A
出版信息
J Exp Med. 1985 Feb 1;161(2):332-44. doi: 10.1084/jem.161.2.332.
Abstract
Pilocarpine-induced saliva of the tick, Ixodes dammini, inhibited platelet aggregation triggered by ADP and collagen, as well as platelet-aggregation factor. In addition, we found apyrase activity (which degrades ATP and ADP to AMP and orthophosphate) and an anticoagulant. We showed the presence of prostaglandin E2 (PGE2) by bioassay and radioimmunoassay. This saliva inhibited interleukin 2 production by T cell hybridomas, an activity consistent with that of PGE2. A kininase was demonstrated, and this may counteract the algesia- and edema-promoting properties of PGE2. Together, these salivary components produce antihemostatic, antiinflammatory, and immunosuppressive effects that may facilitate feeding, as well as transmission of tick-borne pathogens.
摘要
达米尼硬蜱毛果芸香碱诱导的唾液可抑制由二磷酸腺苷（ADP）、胶原蛋白以及血小板聚集因子引发的血小板聚集。此外，我们发现了腺苷三磷酸双磷酸酶活性（将三磷酸腺苷（ATP）和二磷酸腺苷（ADP）降解为单磷酸腺苷（AMP）和正磷酸盐）以及一种抗凝剂。通过生物测定和放射免疫测定，我们证实了前列腺素E2（PGE2）的存在。这种唾液可抑制T细胞杂交瘤产生白细胞介素2，这一活性与PGE2的活性一致。已证实存在一种激肽释放酶，它可能会抵消PGE2促进疼痛和水肿的特性。这些唾液成分共同产生抗止血、抗炎和免疫抑制作用，这可能有助于蜱虫进食以及传播蜱传病原体。
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Antihemostatic, antiinflammatory, and immunosuppressive properties of the saliva of a tick, Ixodes dammini.达米尼硬蜱唾液的抗止血、抗炎和免疫抑制特性。
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