Christensen T, Bendix T, Kehlet H
Br J Surg. 1982 Jul;69(7):417-9. doi: 10.1002/bjs.1800690721.
Subjective feelings of fatigue were assessed before operation and 10, 20 and 30 days after uncomplicated elective abdominal surgery in 16 otherwise healthy patients, using a constructed fatigue scale model. In addition, all patients had an orthostatic stress test performed at the same times. Six of the patients also underwent a bicycle ergometer test measuring heart rate and oxygen consumption. Subjective feelings of fatigue were increased (P less than 0.01) at all three postoperative observations, and only 5 of 16 patients returned to their preoperative level. The increased subjective feeling of fatigue correlated positively (RS = 0.53, P less than 0.001) with the increased pulse rate seen during orthostatic stress after operation. Heart rate was about 5 per cent higher (n.s.) after operation when bicycling at the same work loads, while oxygen consumption decreased by about 2 per cent (P less than 0.01) at all three postoperative bicycle tests. It is concluded that even electric uncomplicated abdominal surgery is followed by a pronounced feeling of fatigue, which may persist 1 month after surgery in about one-third of patients. The fatigue scale model seems applicable for future studies on the pathogenesis and treatment of the postoperative fatigue syndrome.
在16名其他方面均健康的患者中，使用构建的疲劳量表模型，在择期腹部手术前以及术后10天、20天和30天评估主观疲劳感受。此外，所有患者在相同时间进行了直立应激试验。其中6名患者还进行了测量心率和耗氧量的自行车测力计测试。在术后所有三个观察时间点，主观疲劳感受均增加（P<0.01），16名患者中只有5名恢复到术前水平。术后主观疲劳感受的增加与直立应激期间观察到的脉搏率增加呈正相关（RS=0.53，P<0.001）。在相同工作负荷下骑自行车时，术后心率约高5%（无统计学意义），而在术后所有三次自行车测试中，耗氧量均下降约2%（P<0.01）。结论是，即使是简单的腹部手术之后也会出现明显的疲劳感，约三分之一的患者术后疲劳感可能持续1个月。疲劳量表模型似乎适用于未来关于术后疲劳综合征发病机制和治疗的研究。
