Fei Guofang, Yan Wei, Gan Yuehua
Guofang Fei Department of Anesthesiology, Huzhou Maternity & Child Health Care Hospital, 2 East Street, Huzhou City, Zhejiang Province, P.R. China.
Wei Yan Department of Anesthesiology, Huzhou Maternity & Child Health Care Hospital, 2 East Street, Huzhou City, Zhejiang Province, P.R. China.
Pak J Med Sci. 2024 Sep;40(8):1781-1785. doi: 10.12669/pjms.40.8.9883.
To assess the effect of subanesthetic dose of esketamine in combination with propofol on the incidence of postoperative fatigue syndrome (POFS) in patients who underwent gastroenterological endoscopy under anaesthesia.
Clinical data of 160 patients who underwent gastroenterological endoscopy under anaesthesia in Huzhou Maternity & Child Health Care Hospital from January to December 2022, ASA Grade- I and II, were retrospectively selected. According to the records, patients were grouped based on the administered anesthetic. Patients who received 0.2 mg/kg of esketamine and 2~2.5mg/kg of propofol comprised Group-E, and patients who were administered one μg/kg of fentanyl and 2 - 2.5mg/kg of propofol comprised Group-F. Mean arterial pressure (MAP), oxygen saturation (SpO) and heart rate (HR) were recorded before the operation (T), after anesthesia (T), three minutes after the gastroscope was inserted (T), five minutes after the colonoscope was inserted (T) and at the end of the operation (T). Operating time, recovery time, propofol dosage and incidence of adverse reactions in the two groups were recorded. The Christensen scores and the incidence of POFS of all patients on Day-I before operation and 1st, 3rd, and 5th days after the operation were recorded.
Compared with T, MAP, SpO and HR in both groups of patients decreased at T, T, T and T (<0.05). MAP, SpO and HR of patients in Group-E were significantly higher compared to Group-F at T, T, T and T (<0.05). Compared with Group-F, the recovery time, intraoperative bradycardia and respiratory depression in Group-E were significantly lower (<0.05), and Christensen scores and the incidence of POFS decreased significantly on the 1st, 3rd, and 5th day after the operation (<0.05).
Subanesthetic dose of esketamine combined with propofol can reduce POFS and postoperative adverse reactions in patients undergoing gastroenterological endoscopy.
评估亚麻醉剂量的艾司氯胺酮联合丙泊酚对接受麻醉下胃肠内镜检查患者术后疲劳综合征（POFS）发生率的影响。
回顾性选取2022年1月至12月在湖州市妇幼保健院接受麻醉下胃肠内镜检查的160例患者的临床资料，美国麻醉医师协会（ASA）分级为Ⅰ级和Ⅱ级。根据记录，患者根据所使用的麻醉剂进行分组。接受0.2mg/kg艾司氯胺酮和2~2.5mg/kg丙泊酚的患者组成E组，接受1μg/kg芬太尼和2 - 2.5mg/kg丙泊酚的患者组成F组。记录手术前（T0）、麻醉后（T1）、胃镜插入后三分钟（T2）、结肠镜插入后五分钟（T3）和手术结束时（T4）的平均动脉压（MAP）、血氧饱和度（SpO₂）和心率（HR）。记录两组的手术时间、恢复时间、丙泊酚用量和不良反应发生率。记录所有患者术前第1天以及术后第1、3和5天的克里斯滕森评分和POFS发生率。
与T0相比，两组患者在T1、T2、T3和T4时的MAP、SpO₂和HR均降低（P<0.05）。在T1、T2、T3和T4时，E组患者的MAP、SpO₂和HR显著高于F组（P<0.05）。与F组相比，E组的恢复时间、术中心动过缓和呼吸抑制显著降低（P<0.05），术后第1、3和5天的克里斯滕森评分和POFS发生率显著降低（P<0.05）。
亚麻醉剂量的艾司氯胺酮联合丙泊酚可降低接受胃肠内镜检查患者的POFS及术后不良反应。
