Wright G L, Bookout C
Can J Physiol Pharmacol. 1982 May;60(5):622-7. doi: 10.1139/y82-084.
The effect of the subcutaneous injection of plasma or erythrocytes on the blood pressure of Sprague-Dawley (S-D), Wistar-Kyoto (WKy), and spontaneously hypertensive (SH) rats was examined over a 3-week period. The injection of plasma produced no detectable alteration in blood pressure in either the normotensive or hypertensive strains. The injection of red cells from WKy rats had no effect on the blood pressure of S-D rats, whereas a moderate (20%) elevation was noted in WKy and SH rats which received erythrocytes from S-D and WKy rats, respectively. The injection of red cells from SH rats produced no effect on S-D rats, a moderate (20%) elevation of the blood pressure of WKy rats, and a marked (42%) increase in the blood pressure of SH rats. Despite the lack of effect of erythrocytes on the resting blood pressure of S-D rats, it was found that these animals exhibit a transient increase in the blood pressure response to norepinephrine (NE) following a single injection of SH red cells. The results suggest the presence of a substance in SH erythrocytes which enhances the pressor response to NE and produces an elevation of resting blood pressure. This substance also appears to occur to some extent in the red cells of S-D and WKy animals; the manifestation of its action on blood pressure elevation is determined to a significant degree by the intrinsic resistance or susceptibility of the animal.
在3周的时间内，研究了皮下注射血浆或红细胞对斯普拉格-道利（S-D）大鼠、Wistar-Kyoto（WKy）大鼠和自发性高血压（SH）大鼠血压的影响。注射血浆后，无论是正常血压还是高血压品系的大鼠，血压均未出现可检测到的变化。注射WKy大鼠的红细胞对S-D大鼠的血压没有影响，而分别接受来自S-D大鼠和WKy大鼠红细胞注射的WKy大鼠和SH大鼠，血压出现了中度（20%）升高。注射SH大鼠的红细胞对S-D大鼠没有影响，使WKy大鼠血压中度（20%）升高，使SH大鼠血压显著（42%）升高。尽管红细胞对S-D大鼠的静息血压没有影响，但发现单次注射SH红细胞后，这些动物对去甲肾上腺素（NE）的血压反应会出现短暂升高。结果表明，SH红细胞中存在一种物质，它能增强对NE的升压反应并使静息血压升高。这种物质在S-D和WKy动物的红细胞中似乎也有一定程度的存在；其对血压升高作用的表现很大程度上取决于动物的内在抵抗力或易感性。
