Yokoyama M, Kitamura Y, Kohrogi T, Miyoshi I
Cancer Res. 1982 Sep;42(9):3806-9.
The pathogenesis of papillomas which developed spontaneously in the forestomach of WB X C57BL/6 F1-W/Wv mutant mice was investigated. The thickness of the forestomach epithelium was used as a quantitative index for development of papillomas. From the 15th day after birth, the forestomach epithelium of the W/Wv mice was significantly thicker than that of the congenic +/+ mice. Administration of aromatic retinoic acid analog (ethyl all-trans-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-3,7-dimethyl-2,4,6,8 -nonatetraenoate) did not suppress development of papillomas. Since papillomas did not appear in the stomach which was removed from the W/Wv embryos and grafted to the s.c. space produced in the back of the adult mice and since a considerable amount of bile reflux preceded development of papillomas, bile reflux may be a cause of papillomas in W/Wv mice.
对WB×C57BL/6 F1-W/Wv突变小鼠前胃中自发形成的乳头状瘤的发病机制进行了研究。前胃上皮厚度被用作乳头状瘤发展的定量指标。从出生后第15天起，W/Wv小鼠的前胃上皮明显比同基因的+/+小鼠厚。给予芳香维甲酸类似物（乙基全反式-9-(4-甲氧基-2,3,6-三甲基苯基)-3,7-二甲基-2,4,6,8-壬四烯酸酯）并不能抑制乳头状瘤的发展。由于从W/Wv胚胎中取出并移植到成年小鼠背部皮下空间的胃中未出现乳头状瘤，且在乳头状瘤发展之前有相当量的胆汁反流，胆汁反流可能是W/Wv小鼠乳头状瘤的一个原因。
