Yokoyama M, Tatsuta M, Baba M, Kitamura Y
Gastroenterology. 1982 May;82(5 Pt 1):857-63.
The chronic antral ulcer developed spontaneously in (WB X C57BL/6)F1-W/WV mice. Natural history of the ulcer was investigated to make clear the mechanisms involved in the development of ulcer in this mutant mouse. Although no histopathologic abnormalities of the stomach were detected at the fifth day after birth, erosions developed at the tenth day and the severity of the ulcerative lesions advanced with age. Antral pH of the W/WV mice was higher than that of the congenic +/+ mice, and the content of gastrin in the glandular stomach of the former was lower than that of the latter. Therefore, hyperacidity cannot be the cause of the ulcer in the W/WV mice. Bilirubin was demonstrable in the stomach contents of the suckling W/WV mice. After subcutaneous injection of [35S]sulfobromophthalein, the 35S radio-activity in the stomach contents of the 10-day-old W/WV mice was about 40 times as great as that observed in the +/+ littermates. As the peak of the bile reflux occurred shortly before the development of obvious ulcer that penetrated beyond the muscularis mucosae, the bile reflux could be a cause rather than a result of the ulcer.
慢性胃窦溃疡在（WB×C57BL/6）F1-W/WV小鼠中自发形成。对溃疡的自然病程进行了研究，以明确该突变小鼠溃疡发生的机制。虽然出生后第5天未检测到胃的组织病理学异常，但在第10天出现糜烂，且溃疡性病变的严重程度随年龄增长而加重。W/WV小鼠的胃窦pH值高于同基因的+/+小鼠，前者腺胃中的胃泌素含量低于后者。因此，胃酸过多不是W/WV小鼠溃疡的病因。在哺乳期W/WV小鼠的胃内容物中可检测到胆红素。皮下注射[35S]磺溴酞钠后，10日龄W/WV小鼠胃内容物中的35S放射性约为+/+同窝小鼠的40倍。由于胆汁反流的高峰出现在明显溃疡穿透黏膜肌层之前不久，胆汁反流可能是溃疡的原因而非结果。
