Miki K, Ichinose M, Furihata C, Niwa H, Oka H, Oda T, Matsushima T
Clin Chim Acta. 1982 Jun 3;121(3):337-44. doi: 10.1016/0009-8981(82)90243-1.
Pepsinogen level, expressed as the potential peptic activity of pepsinogen was determined by a fluorescent microassay using succinyl albumin as substrate, in biopsy specimens from the gastroduodenal mucosa of 95 subjects. The following results were obtained: (1) pepsinogen level in the gastric mucosa becomes progressively higher from pylorus to corpus (p less than 0.001); (2) pepsinogen level in the gastroduodenal mucosa of duodenal ulcer was significantly higher than that of normal mucosa or gastric ulcer (p less than 0.001); (3) the difference in pepsinogen level between the gastric mucosa with and without intestinal metaplasia was statistically significant (p less than 0.01); (4) the correlation between the histology of gastric glands and pepsinogen level was fundic gland greater than intermediate gland greater than pyloric gland (p less than 0.001).
以胃蛋白酶原的潜在消化活性表示的胃蛋白酶原水平，采用以琥珀酰白蛋白为底物的荧光微量测定法，在95名受试者的胃十二指肠黏膜活检标本中进行测定。得到以下结果：(1) 胃黏膜中的胃蛋白酶原水平从幽门到胃体逐渐升高（p<0.001）；(2) 十二指肠溃疡患者胃十二指肠黏膜中的胃蛋白酶原水平显著高于正常黏膜或胃溃疡患者（p<0.001）；(3) 有肠化生和无肠化生的胃黏膜之间胃蛋白酶原水平的差异具有统计学意义（p<0.01）；(4) 胃腺组织学与胃蛋白酶原水平之间的相关性为：胃底腺>中间腺>幽门腺（p<0.001）。
