Stearns M P
Clin Otolaryngol Allied Sci. 1982 Jun;7(3):161-4. doi: 10.1111/j.1365-2273.1982.tb01577.x.
The purpose of this study was to investigate the effect of pre-operative radiotherapy on nerve grafting, using the rat sciatic nerve as an experimental model. Two groups of 10 rats were used, one group irradiated, the other not. In each rat a 5 mm section of one sciatic nerve was excised then replaced and sutured into position. Nerve regeneration was investigated by expressing the area of the mass action potential in the regenerated nerve as a percentage of the mass action potential in the contralateral intact nerve. A significant difference (P less than 0.01) in nerve regeneration was found between the irradiated and non-irradiated animals. In the irradiated group only two animals achieved more than 20% nerve fibre regeneration whilst in the non-irradiated group all but two animals achieved greater than 20% regeneration. These results suggest that pre-operative irradiation has an adverse effect on nerve regeneration.
本研究的目的是利用大鼠坐骨神经作为实验模型，研究术前放疗对神经移植的影响。使用两组各10只大鼠，一组进行照射，另一组不照射。在每只大鼠中，切除一段5毫米的坐骨神经，然后将其替换并缝合到位。通过将再生神经中动作电位的面积表示为对侧完整神经中动作电位面积的百分比来研究神经再生。在照射组和未照射组动物之间发现神经再生存在显著差异（P小于0.01）。在照射组中，只有两只动物的神经纤维再生超过20%，而在未照射组中，除两只动物外，所有动物的再生均超过20%。这些结果表明，术前照射对神经再生有不利影响。
