Gitelis S, Chen P Q, Andersson G B, Galante J O, Rostoker W, Andriacchi T P
Clin Orthop Relat Res. 1982 Sep(169):291-302.
The bone-cement interface is an area of concern in the long-term fixation of endoprostheses. The effect of early weight-bearing on the interface has been discussed as an important parameter influencing the characteristics of the interface. In this study, a total hip arthroplasty was performed in two groups of six dogs each. One group was allowed immediate weight-bearing, while in the other, a knee disarticulation amputation was done to prevent weight-bearing. Three animals of each group were killed at three months and three of each group at six months, and a histological study of the interface was done. No morphologic difference was observed between weight-bearing and nonweight-bearing animals in the interface area. Endosteal bone remodeling occurred regardless of weight-bearing stresses. A fibrous membrane was found between the cement and the endosteal surface of the femur, and membrane thickness was similar in all animals. The membrane between the cement and acetabular bone, however, was consistently thicker. Quantitative studies revealed increased femoral cortical bone resorption in the nonweight-bearing animals.
骨水泥界面是人工关节长期固定中一个备受关注的区域。早期负重对该界面的影响已被视为影响界面特性的一个重要参数进行讨论。在本研究中，对两组犬进行了全髋关节置换术，每组6只。一组允许立即负重，而另一组则进行膝关节离断截肢以防止负重。每组在3个月时处死3只动物，6个月时处死每组另外3只动物，并对界面进行组织学研究。在界面区域，负重和非负重动物之间未观察到形态学差异。无论负重应力如何，骨内膜都会发生骨重塑。在骨水泥与股骨骨内膜表面之间发现了一层纤维膜，所有动物的膜厚度相似。然而，骨水泥与髋臼骨之间的膜始终更厚。定量研究显示，非负重动物的股骨皮质骨吸收增加。
