通过多巴胺阻断消除下体正压产生的利钠反应。

Abolition, by dopamine blockade, of the natriuretic response produced by lower-body positive pressure.

Bennett E D, Tighe D, Wegg W

Clin Sci (Lond). 1982 Oct;63(4):361-6. doi: 10.1042/cs0630361.

Abstract

In a preliminary study, a positive pressure of 25 mmHg applied to the lower body raised right atrial pressure by a mean of 7 mmHg. 2. Sustained application of lower-body positive pressure (LBPP) in six normal adult males increased sodium excretion ([Na]V) from a control level of 126.5 +/- 10 mumol/min to 213 +/- 21 mumol/min (P = 0.003) and fractional sodium excretion (EfNa) from 0.7 +/- 0.1 to 1.2 +/- 0.1 (P = 0.001). 3. Urine flow (UF) increased from 0.85 +/- 0.07 ml/min to 4.1 +/- 0.8 ml/min (P = 0.002), osmolar clearance (Cosm) from 2.6 +/- 0.13 ml/min to 4.2 +/- 0.4 ml/min (P = 0.003) and free water clearance (CH2O) from -1.75 +/- 0.1 ml/min to -0.1 +/- 0.01 ml/min (P = 0.001). Creatinine clearance (Ccr) showed no significant change. 4. After dopamine blockade with domperidone, LBPP did not cause a rise in [Na]V or EfNa. However, urine flow, Cosm. and CH2O remained significantly above control values, implying persistent suppression of antidiuretic hormone. 5. Dopamine blockade without positive pressure did not affect basal sodium excretion.

摘要

在一项初步研究中，对下半身施加25 mmHg的正压使右心房压力平均升高7 mmHg。2. 对6名正常成年男性持续施加下半身正压（LBPP），使钠排泄量（[Na]V）从对照水平的126.5±10 μmol/min增加至213±21 μmol/min（P = 0.003），钠排泄分数（EfNa）从0.7±0.1增加至1.2±0.1（P = 0.001）。3. 尿流量（UF）从0.85±0.07 ml/min增加至4.1±0.8 ml/min（P = 0.002），渗透清除率（Cosm）从2.6±0.13 ml/min增加至4.2±0.4 ml/min（P = 0.003），自由水清除率（CH2O）从 -1.75±0.1 ml/min增加至 -0.1±0.01 ml/min（P = 0.001）。肌酐清除率（Ccr）无显著变化。4. 用多潘立酮阻断多巴胺后，LBPP未引起[Na]V或EfNa升高。然而，尿流量、Cosm和CH2O仍显著高于对照值，这意味着抗利尿激素持续受到抑制。5. 无正压的多巴胺阻断不影响基础钠排泄。