Gambhir S S, Pradhan S C, Das P K
Eur J Pharmacol. 1982 May 21;80(2-3):231-6. doi: 10.1016/0014-2999(82)90059-0.
Isolated atria of frogs responded to compound 48/80 and d-tubocurarine with a delayed stimulation that showed tachyphylaxis and cross-tachyphylaxis indicating a common indirect mechanism. The blockers of H2-histamine, serotonin and beta-adrenergic receptors did not significantly antagonise these responses. However, in experiments with ex vivo and in vitro indomethacin-treated atria, the stimulant effects of mast cell degranulators were not observed, indicating a possible involvement of the prostaglandins.
青蛙的离体心房对化合物48/80和d -筒箭毒碱产生延迟刺激反应，该反应表现出快速耐受性和交叉快速耐受性，表明存在共同的间接机制。H2 -组胺、5 -羟色胺和β -肾上腺素能受体阻滞剂对这些反应无明显拮抗作用。然而，在离体和体外经吲哚美辛处理的心房实验中，未观察到肥大细胞脱颗粒剂的刺激作用，这表明前列腺素可能参与其中。
