Courpied J P, Deplus P, Barthas J, Forest M, Carlioz A, Vacher-Lavenu M C, Crouzette J, Fournier P, Baufume M
Int Orthop. 1982;6(1):1-7.
The tolerance and response of bone to bioglass have been studied using implants of various chemical constitution in animals. Glass discs were inserted between the inner and outer tables of the skull in 32 rabbits and small glass stick were implanted in the medullary cavity of long bones in 6 dogs. The results were analysed between 6 and 18 months later. High resolution radiographs and histopathological examination were performed. Some glass behaves like an inert material but other specimens are biodegradable and induce a satisfactory bone response in adjacent bone. Any new bone formation does not follow the classical stages of connective tissue, cartilage and woven bone. Bioglass is more suitable for bone than many other materials now in use and further applications in orthopaedic surgery may be considered.
通过在动物体内植入各种化学成分的植入物，对骨骼对生物玻璃的耐受性和反应进行了研究。将玻璃圆盘插入32只兔子颅骨的内外板之间，并将小玻璃棒植入6只狗长骨的髓腔内。在6至18个月后对结果进行分析。进行了高分辨率X光片和组织病理学检查。一些玻璃表现得像惰性材料，但其他标本是可生物降解的，并在相邻骨骼中诱导出令人满意的骨反应。任何新骨形成都不遵循结缔组织、软骨和编织骨的经典阶段。生物玻璃比目前使用的许多其他材料更适合用于骨骼，可能会考虑在骨科手术中的进一步应用。
