Sharplin J, Franko A J
Int J Radiat Oncol Biol Phys. 1982 Jun;8(6):1065-9. doi: 10.1016/0360-3016(82)90179-1.
The lungs of Balb/c mice were irradiated with doses of 200 to 1300 rad and excised and weighed three days to 20 weeks later. In all cases the wet weights were increased relative to unirradiated controls. The weight increases were dose-dependent up to 1000 rad. The largest weight increase was 28%. Comparison of the wet and dry weights of irradiated and control lungs indicated that the material responsible for the weight increase was intermediate in water content between normal lung tissue and plasma, whereas the water content of pulmonary edema fluid produced by adrenalin injection was similar to plasma. Protection of the mediastinum during irradiation did not affect the weight increase appreciably.
用200至1300拉德的剂量对Balb/c小鼠的肺部进行照射，在照射后三天至20周后将其切除并称重。在所有情况下，与未照射的对照组相比，湿重均增加。在剂量达到1000拉德之前，重量增加呈剂量依赖性。最大的重量增加为28%。对照射组和对照组肺脏的湿重和干重进行比较表明，导致重量增加的物质含水量介于正常肺组织和血浆之间，而肾上腺素注射所产生的肺水肿液的含水量与血浆相似。照射期间对纵隔的防护对重量增加没有明显影响。
