嗜唾液节杆菌中神经氨酸酶诱导的结构要求。
Structural requirements for neuraminidase induction in Arthrobacter sialophilus.
作者信息
Flashner M, Kessler J, Tanenbaum S W
出版信息
J Bacteriol. 1982 Sep;151(3):1630-2. doi: 10.1128/jb.151.3.1630-1632.1982.
Abstract
The effectiveness of 13 N-acetylneuraminic acid derivatives as potential inducers of Arthrobacter sialophilus neuraminidase were examined. N-Acetylneuraminic acid nitrogen and thioglycosides were not inducers, whereas 2,3-dehydro-N-acetylneuraminic acid, a transition state analog for neuraminidases, was the most effective inductive ligand. The C-4 hydroxyl function of N-acetylneuraminic acid was essential for enzyme derepression.
摘要
研究了13种N-乙酰神经氨酸衍生物作为嗜唾液节杆菌神经氨酸酶潜在诱导剂的有效性。N-乙酰神经氨酸氮苷和硫苷不是诱导剂，而2,3-脱氢-N-乙酰神经氨酸作为神经氨酸酶的过渡态类似物，是最有效的诱导配体。N-乙酰神经氨酸的C-4羟基官能团对酶的去阻遏作用至关重要。
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本文引用的文献
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Carbohydr Res. 1981 Aug 1;94(2):123-30. doi: 10.1016/s0008-6215(00)80711-9.
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