Al-Khayat T M, Al-Darweesh T M, Islam M S
J Clin Chem Clin Biochem. 1982 May;20(5):281-5. doi: 10.1515/cclm.1982.20.5.281.
The administration of thyroxine produces a significant increase in the copper, magnesium, iron and zinc contents of liver, with a concomitant decrease of heart iron. Magnesium in heart tissues was also increased. The administration of antithyroid drugs produces a significant decrease in the concentration of the same metals in the liver with concomitant increases in kidney copper and calcium, and in heart magnesium and calcium. Brain magnesium was found to be significantly decreased after antithyroid treatment and increased to a lesser extent after thyroxine administration. Thyroidectomy did not produce an appreciable effect on minerals in various tissues, except heart zinc which was significantly decreased. These findings suggest the involvement of thyroid hormones in tissue mineral metabolism, especially in the liver.
甲状腺素的施用会使肝脏中的铜、镁、铁和锌含量显著增加，同时心脏中的铁含量会减少。心脏组织中的镁含量也会增加。抗甲状腺药物的施用会使肝脏中相同金属的浓度显著降低，同时肾脏中的铜和钙、心脏中的镁和钙会增加。抗甲状腺治疗后发现脑镁显著降低，甲状腺素施用后则有较小程度的增加。甲状腺切除术对各种组织中的矿物质没有明显影响，除了心脏锌显著降低。这些发现表明甲状腺激素参与组织矿物质代谢，尤其是在肝脏中。
