Anasuya A
J Nutr. 1982 Sep;112(9):1787-95. doi: 10.1093/jn/112.9.1787.
The effect of fluoride on urinary calculi formation in young rats was investigated. Two studies, in which rats received diets that included either higher calcium (9 g/kg diet) or normal calcium (5 g/kg diet), were conducted At each level of calcium, one group of rats received a high level of fluoride and another a low level of fluoride in the diet. Rats ingesting high fluoride diets exhibited a higher incidence of crystalluria and bladder stones compared with those receiving low fluoride diets. However, compared with higher calcium diets, normal calcium diets delayed the appearance of crystalluria and produced smaller calculi. Calcium and oxalate were the major components of the calculi. Calculi of rats fed the higher calcium and high fluoride diet contained relatively less protein and more calcium compared with calculi formed in rats ingesting the higher calcium and low fluoride diet. The concentration of fluoride in calculi from rats fed high fluoride diets was significantly higher than that of calculi from rats fed low fluoride diets. A significant positive correlation between calcium and fluoride concentration of calculi was observed in rats fed the higher calcium diet only. These studies indicate that ingestion of excess fluoride facilities calcium oxalate crystalluria and promotes the formation of bladder stones in rats, under the experimental conditions used.
研究了氟化物对幼鼠尿路结石形成的影响。进行了两项研究，其中大鼠分别接受高钙（9克/千克日粮）或正常钙（5克/千克日粮）的日粮。在每个钙水平下，一组大鼠在日粮中接受高氟水平，另一组接受低氟水平。与接受低氟日粮的大鼠相比，摄入高氟日粮的大鼠结晶尿和膀胱结石的发生率更高。然而，与高钙日粮相比，正常钙日粮延迟了结晶尿的出现并产生了更小的结石。钙和草酸盐是结石的主要成分。与摄入高钙低氟日粮的大鼠形成的结石相比，喂食高钙高氟日粮的大鼠的结石含有相对较少的蛋白质和较多的钙。喂食高氟日粮的大鼠结石中的氟浓度明显高于喂食低氟日粮的大鼠结石中的氟浓度。仅在喂食高钙日粮的大鼠中观察到结石中钙和氟浓度之间存在显著的正相关。这些研究表明，在所用的实验条件下，摄入过量氟会促进大鼠草酸钙结晶尿并促进膀胱结石的形成。
