Teodorczyk-Injeyan J A, Jewett M A, Falk R E
J Reprod Immunol. 1982 May;4(2):67-78. doi: 10.1016/0165-0378(82)90038-9.
Mouse primitive teratocarcinoma cells share a common surface antigen with morulae, preimplantation embryo cells and murine and human spermatozoa. 129/Sv mice were immunized with either spermatozoa and subsequently inoculated with various doses of teratocarcinoma 6050. A significant inhibition or acceleration of tumor growth was observed when compared with controls immunized with compatible fibroblasts. These effects were sex-dependent, both the incidence and tumor growth being suppressed in sperm-immunized males. The opposite effects were observed in sperm-presensitized females. Immune sera obtained from both male and female 129/Sv mice exhibited a high binding activity to human spermatozoa when tested in a cellular radioimmunoassay. Thus, immunization with sperm antigens provides immunotherapeutic and/or enhancing effects in male and female 129/Sv mice, respectively.
