Uza G, Cristea A, Cucuianu M P
J Clin Lab Immunol. 1982 Jun;8(2):101-5.
When compared to values obtained in normalweight, normolipidemic control subjects, the level of complement C3 protein and total complement activity (CH50) were found to be obviously decreased in patients with decompensated cirrhosis of the liver and slightly but significantly increased in subjects with type IIb and type IV hyperlipoproteinemia. C3 protein level was positively correlated with the concentration of serum cholesterol, the logarithm of serum triglyceride concentration, serum pseudocholinesterase and total complement activity. There were no significant differences concerning C3 protein level between hyperlipidemic subjects with clinical atherosclerosis and those without documented vascular disease. It is suggested that accelerated lipoprotein turnover occurring in many subjects with type IIb and type IV hyperlipoproteinemia might enhance the synthesis of several liver produced plasma enzymes and proteins including the C3 protein of the complement system.
与正常体重、血脂正常的对照受试者所测得的值相比，失代偿期肝硬化患者的补体C3蛋白水平和总补体活性（CH50）明显降低，而IIb型和IV型高脂蛋白血症患者的补体C3蛋白水平和总补体活性则略有升高，但差异有统计学意义。C3蛋白水平与血清胆固醇浓度、血清甘油三酯浓度的对数、血清假性胆碱酯酶及总补体活性呈正相关。有临床动脉粥样硬化的高脂血症患者与无血管疾病记录的患者之间，C3蛋白水平无显著差异。提示许多IIb型和IV型高脂蛋白血症患者中发生的脂蛋白周转加速可能会增强几种肝脏产生的血浆酶和蛋白质的合成，包括补体系统的C3蛋白。
