Cucuianu M P, Cristea A, Roman S, Missits I
Clin Chim Acta. 1981 Mar 5;110(2-3):147-55. doi: 10.1016/0009-8981(81)90344-2.
When compared to values obtained in healthy normolipidemic normal weight control subjects, the plasma antithrombin III level determined by immunological, clotting and thrombin-agarose diffusion techniques was found to be obviously decreased in patients with decompensated cirrhosis of the liver and slightly but significantly increased in hyperlipidemic and especially in hypertriglyceridemic subjects. Plasma antithrombin III was positively correlated with serum cholesterol level, the logarithm of serum triglyceride concentration and serum pseudocholinesterase activity. A weaker correlation between plasma fibrinogen and antithrombin III was noted in the investigated clinical material. It is suggested that the accelerated fatty acid and lipoprotein turnover occurring in many subjects with type IIb and type IV hyperlipoproteinemia might be accompanied by an enhanced hepatic protein synthesis involving various liver secretion enzymes and clotting factors as well as antithrombin III.
与健康的血脂正常、体重正常的对照受试者所获得的值相比，通过免疫学、凝血和凝血酶 - 琼脂糖扩散技术测定的血浆抗凝血酶III水平在失代偿期肝硬化患者中明显降低，而在高脂血症患者尤其是高甘油三酯血症患者中略有但显著升高。血浆抗凝血酶III与血清胆固醇水平、血清甘油三酯浓度的对数以及血清假性胆碱酯酶活性呈正相关。在所研究的临床材料中，血浆纤维蛋白原与抗凝血酶III之间的相关性较弱。有人提出，许多IIb型和IV型高脂蛋白血症患者中发生的脂肪酸和脂蛋白周转加速，可能伴随着肝脏蛋白质合成的增强，这涉及各种肝脏分泌酶、凝血因子以及抗凝血酶III。
