Wahl P, Deppermann D, Hasslacher C
Kidney Int. 1982 May;21(5):744-9. doi: 10.1038/ki.1982.92.
HGBM were isolated from kidneys of 22 diabetic patients and 32 normal control persons. All diabetic kidneys showed severe alterations of glomerulosclerosis. The amount of basement membranes isolated from diabetic kidneys was significantly higher. The HGBM preparations were individually analyzed for phosphorus, DNA, amino acids, and carbohydrates. The cystine concentration was found to be lower in the diabetic than in normal HGBM. Contrary to other reports, there was no increase in the amounts of hydroxylysine, glucose, and galactose, nor was there a decrease in the lysine content. Glucose and mannose were shown to be significantly lower in the diabetic HGBM. The mean value for sialic acid content was lower in diabetic HGBM; the value did not reach statistical significance. This study's data could not confirm the finding of a specific alteration of diabetic HGBM as proposed previously.
从22名糖尿病患者和32名正常对照者的肾脏中分离出人肾小球基底膜（HGBM）。所有糖尿病肾脏均显示出严重的肾小球硬化改变。从糖尿病肾脏分离出的基底膜数量明显更高。对HGBM制剂分别进行磷、DNA、氨基酸和碳水化合物分析。发现糖尿病患者的HGBM中胱氨酸浓度低于正常HGBM。与其他报告相反，羟赖氨酸、葡萄糖和半乳糖的含量没有增加，赖氨酸含量也没有减少。糖尿病HGBM中的葡萄糖和甘露糖含量显著降低。糖尿病HGBM中唾液酸含量的平均值较低；该值未达到统计学显著性。本研究的数据无法证实先前提出的糖尿病HGBM存在特定改变的发现。
