Canivet J, Cruz A, Moreau-Lalande H
Metabolism. 1979 Dec;28(12):1206-10. doi: 10.1016/0026-0495(79)90132-x.
Since the biochemical composition of the diabetic glomerular basement membrane is still a controversial area, a study was carried out using kidneys from seven diabetic and seven nondiabetic subjects. In diabetic membranes, the glycine, hydroxylysine, glucose, galactose, and hydroxylysine-linked disaccharide unit content was increased together with a decrease in the half-cystine and sialic acid content. These findings support the view of a biochemical alteration in the human diabetic glomerular basement membrane.
由于糖尿病肾小球基底膜的生化组成仍是一个有争议的领域，因此使用了7名糖尿病患者和7名非糖尿病患者的肾脏进行了一项研究。在糖尿病患者的基底膜中，甘氨酸、羟赖氨酸、葡萄糖、半乳糖和羟赖氨酸连接的二糖单位含量增加，同时半胱氨酸和唾液酸含量减少。这些发现支持了人类糖尿病肾小球基底膜存在生化改变的观点。
