Kawamura M, Nagano M
Contrib Nephrol. 1977;6:23-33. doi: 10.1159/000399749.
The alteration of glycoprotein in the glomerular basement membrane in diabetic glomerulosclerosis was studied with preparative polyacrylamide gel electrophoresis by Uniphor column. Normal glomerular basement membrane was fractionated into 32 glycoprotein fractions. Decrease in sialic acid residue of sialoprotein was the characteristic finding observed in diabetic glomerulosclerosis. A hypothesis which explains the alteration of sialoglycoprotein is proposed.
采用Uniphor柱制备聚丙烯酰胺凝胶电泳法研究了糖尿病肾小球硬化症患者肾小球基底膜中糖蛋白的变化。正常肾小球基底膜被分离成32个糖蛋白组分。糖尿病肾小球硬化症的特征性表现是涎蛋白中唾液酸残基减少。本文提出了一个解释唾液酸糖蛋白变化的假说。
