长期给大鼠服用抗酸剂所致的壁细胞增生。
Parietal cell hyperplasia induced by long-term administration of antacids to rats.
作者信息
Mazzacca G, Cascione F, Budillon G, D'Agostino L, Cimino L, Femiano C
出版信息
Gut. 1978 Sep;19(9):798-801. doi: 10.1136/gut.19.9.798.
Suspension of magnesium and aluminum hydroxide (30--60 mEq/24h) or a comparable volme of water was orally administered by gastric intubation to two groups of 20 male Wistar rats each over 60 days. The antacid treatment led to a significant increase in the height (0.464 +/- 0.02 mm v. 0.318 +/- 0.06) and in the volume (472 +/- 32 mm3v.328 +/- 45) of the fundic mucosa of the stomach, in the average count of parietal cells per unit area of the mucosa (32.37 +/- 1.8 v. 22.3 +/- 1.6), and in the total parietal cell population of the stomach (53.6 +/- 3.5 x 10(6) v. 43.2 +/- 3.7 x 10(6)). Furthermore fasting serum gastrin concentration was significantly higher in the antacid treated rats (81.2 +/- 7.4 pg/ml) than in control animals (56.9 +/- 6.9 pg/ml).
通过胃管向两组各20只雄性Wistar大鼠口服给予氢氧化镁和氢氧化铝混悬液（30 - 60 mEq/24小时）或等量的水，持续60天。抗酸治疗导致胃底黏膜高度显著增加（0.464±0.02毫米对0.318±0.06）、体积显著增加（472±32立方毫米对328±45），黏膜单位面积壁细胞平均计数显著增加（32.37±1.8对22.3±1.6），以及胃壁细胞总数显著增加（53.6±3.5×10⁶对43.2±3.7×10⁶）。此外，抗酸治疗的大鼠空腹血清胃泌素浓度（81.2±7.4 pg/ml）显著高于对照动物（56.9±6.9 pg/ml）。
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