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年龄对人淋巴细胞辐射敏感性的影响。简短报告。

Effect of age on sensitivity of human lymphocytes to radiation. A brief note.

作者信息

Kutlaca R, Seshadri R, Morley A A

出版信息

Mech Ageing Dev. 1982 Jun;19(2):97-101. doi: 10.1016/0047-6374(82)90001-x.

DOI:10.1016/0047-6374(82)90001-x
PMID:7109715
Abstract

Survival of human lymphocytes after X-ray and ultraviolet irradiation was studied in individuals of various ages using a technique of cloning in soft agar. There was no effect of age on survival after ultraviolet irradiation but lymphocytes from elderly individuals were approximately twice as sensitive to X-radiation as lymphocytes from young individuals. The results are relevant to the possible importance of DNA damage and repair in cellular ageing.

摘要

使用软琼脂克隆技术,对不同年龄段个体的人类淋巴细胞在X射线和紫外线照射后的存活情况进行了研究。紫外线照射后,年龄对细胞存活没有影响,但老年个体的淋巴细胞对X射线的敏感性大约是年轻个体淋巴细胞的两倍。这些结果与DNA损伤和修复在细胞衰老中可能的重要性相关。

相似文献

1
Effect of age on sensitivity of human lymphocytes to radiation. A brief note.年龄对人淋巴细胞辐射敏感性的影响。简短报告。
Mech Ageing Dev. 1982 Jun;19(2):97-101. doi: 10.1016/0047-6374(82)90001-x.
2
Radiation sensitivity of human lymphocytes.人类淋巴细胞的辐射敏感性。
Mutat Res. 1982 May;94(1):125-31. doi: 10.1016/0027-5107(82)90174-9.
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Serum effects on DNA repair in human cells.血清对人类细胞中DNA修复的影响。
Chem Biol Interact. 1985 Aug-Sep;54(3):325-35. doi: 10.1016/s0009-2797(85)80173-3.
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Mutations in human lymphocytes: effect of X- and UV-irradiation.人类淋巴细胞中的突变:X射线和紫外线辐射的影响。
Mutat Res. 1984 Aug;140(4):223-7. doi: 10.1016/0165-7992(84)90082-4.
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Sensitivity of mononuclear cells to UV radiation.单核细胞对紫外线辐射的敏感性。
Photochem Photobiol. 1979 May;29(5):1045-7. doi: 10.1111/j.1751-1097.1979.tb07813.x.
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Cytokinesis-block micronucleus method in human lymphocytes: effect of in vivo ageing and low dose X-irradiation.人淋巴细胞中的胞质分裂阻滞微核法:体内衰老和低剂量X射线照射的影响
Mutat Res. 1986 Jul;161(2):193-8. doi: 10.1016/0027-5107(86)90010-2.
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Role of solar conditioning in DNA repair response and survival of human epidermal keratinocytes following UV irradiation.日光预处理在紫外线照射后人表皮角质形成细胞DNA修复反应及存活中的作用。
J Invest Dermatol. 1985 Aug;85(2):93-7. doi: 10.1111/1523-1747.ep12276441.
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Familial melanoma associated with dominant ultraviolet radiation sensitivity.与显性紫外线辐射敏感性相关的家族性黑色素瘤。
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[Release of substances from human peripheral blood lymphocytes irradiated by short-wave UV rays].[短波紫外线照射后人外周血淋巴细胞中物质的释放]
Tsitologiia. 1984 Jan;26(1):102-8.
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Ultraviolet radiation sensitivity of proliferating and differentiated human neuroblastoma cells.增殖和分化的人神经母细胞瘤细胞的紫外线辐射敏感性
Int J Radiat Biol Relat Stud Phys Chem Med. 1982 May;41(5):547-56. doi: 10.1080/09553008214550621.

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