Clapp J F, Abrams R M
Gynecol Obstet Invest. 1978;9(1):32-9. doi: 10.1159/000300968.
Umbilical blood flow rate (UBF) was measured in 9 exteriorized fetal lambs by weight changes of the fetus during total umbilical vein occlusion. Concentrations of oxygen, lactate and pyruvate in umbilical arterial (UA) and umbilical venous (UV) blood were determined. Rate of fetal oxygen consumption (.QO2) was 5.2 +/- (SEM) 0.48 ml. kg(-1) . min (-1), and was correlated with UBF (r = 0.793), but not with the content of O2 in UA or UV. The UV-UA differences in lactate/pyruvate ratios indicated varying degrees of anaerobic metabolism in those fetuses with highest UBF and .QO2, but not in poorly perfused fetuses with low .QO2. Fetal exteriorization can result in inadequate perfusion of fetal tissue, lowering of fetal oxygen consumption and some anaerobic metabolism.
通过在完全阻断脐静脉期间胎儿体重变化，对9只体外胎儿羔羊的脐血流量（UBF）进行了测量。测定了脐动脉（UA）血和脐静脉（UV）血中的氧、乳酸和丙酮酸浓度。胎儿耗氧率（.QO2）为5.2±（标准误）0.48 ml·kg⁻¹·min⁻¹，且与脐血流量相关（r = 0.793），但与脐动脉或脐静脉中的氧含量无关。脐静脉 - 脐动脉乳酸/丙酮酸比值的差异表明，在脐血流量和耗氧率最高的胎儿中存在不同程度的无氧代谢，而在脐血流量低、耗氧率低且灌注不良的胎儿中则不存在。胎儿体外化可导致胎儿组织灌注不足、胎儿耗氧量降低和一些无氧代谢。
