Grzanna R, Shultz L D
Life Sci. 1982 Jun 7;30(23):1959-64. doi: 10.1016/0024-3205(82)90434-9.
W/WV mice are severely deficient in mast cells. The absence of mast cells in skin and salivary glands was found to be paralleled by a drastic decrease of the histamine levels in these tissues when compared to non-anemic +/+ control mice. Brains of W/WV mice are also devoid of mast cells. A comparison of the histamine concentrations in several brain regions of W/WV mice and controls revealed a moderate decrease in cerebral cortex, thalamus, hypothalamus and midbrain but no change in pons, medulla and cerebellum. These findings provide strong evidence that mast cells contribute to the histamine content in forebrain regions but not in hindbrain regions. It is speculated that there may exist histaminergic neurons intrinsic to the medulla and pons.
W/WV小鼠严重缺乏肥大细胞。与非贫血的+/+对照小鼠相比，发现皮肤和唾液腺中肥大细胞的缺失与这些组织中组胺水平的急剧下降同时出现。W/WV小鼠的大脑也没有肥大细胞。对W/WV小鼠和对照小鼠几个脑区中组胺浓度的比较显示，大脑皮层、丘脑、下丘脑和中脑有中度下降，但脑桥、延髓和小脑没有变化。这些发现提供了有力证据，表明肥大细胞对前脑区域的组胺含量有贡献，但对后脑区域没有贡献。据推测，延髓和脑桥可能存在内在组胺能神经元。
